University College London

University College London (UCL) London’s Global University was established in 1826, is among the top universities in the UK and ranked in 7th place worldwide in the QS World University Rankings 2015/16. It was also the first UK university to welcome female students on equal terms with men. Academic excellence and conducting research that addresses real-world problems inform its ethos to this day. UCL academics are working at the forefront of their disciplines, collaborating with world-renowned organisations such as Intel, BHP Billiton and NASA and contributing to influential reports for the UN, EU and UK government. UCL’s academic structure consists of 10 faculties, each home to world-class research, teaching and learning in a variety of fields. UCL has 920 professors, more than 5,000 academic and research staff, and a nearly 29,000-strong student community.

The Centre for Computational Science (CCS) at UCL, led by Prof Peter Coveney, is an internationally leading centre for innovative scientific research using high performance computing. CCS is currently comprised of some 20 members and pursues a diverse range of research unified by common computational approaches, from theory and design of algorithms to implementations and middleware on internationally distributed HPC systems. The CCS enjoys numerous successful industrial collaborations with companies such as Unilever, Schlumberger, Microsoft, Pfizer and Fujitsu. The CCS has developed several HPC applications, including the computational fluid dynamics code, HemeLB, for clinical applications in vascular disorders such as intracranial aneurysms. The UCL team also maintains other software, tools and services, including a second HPC code, LB3D, which supports a number of other biomedical studies, along with the Binding Affinity Calculator (BAC), and the Application Hosting Environment (AHE).

The Department of Structural and Molecular Biology is an integral part of the Institute of Structural and Molecular Biology (ISMB), an institute conducting world-class research in the field of protein science. The ISMB is a joint institute between UCL and Birkbeck, primarily constituted of the UCL Department of Structural and Molecular Biology and the Birkbeck College Department of Biological Sciences, but also including the Chemical Biology section of the UCL Department of Chemistry. The department investigates areas of modern biology, biotechnology and medicine at the atomic, molecular, cellular and organism levels.

The National Hospital for Neurology and Neurosurgery (NHNN) is the UK’s largest dedicated neurological and neurosurgical hospital. It provides comprehensive services for the diagnosis, treatment and care of all conditions that affect the brain, spinal cord, peripheral nervous system and muscles. Services include specialist neurosurgery, a brain tumour unit, the Hyper-acute Stroke Unit (HASU), an acute brain injury unit, the National Prion Clinic, a pioneering neuro-rehabilitation unit, the UK’s first interventional MRI scanner, the largest specialised neurosurgical ITU and the only neuromedical ITU in the country. Together with its neighbour, the Institute of Neurology, it is a major international centre for research and training. The Hospital is part of University College London Hospitals NHS Foundation Trust (UCLH).

The Gupta lab, led by Dr Ravindra Gupta, is based in the Division of Infection & Immunity within the Faculty of Medicine at UCL. Their work focuses on four areas; investigating the details of macrophage infection in clinical isolates, exploring viral determinants of successful transmission by examining HIV genes individually from both acute and chronic infection, studying in vitro HIV drug resistance to protease inhibitors and implications for global scale up of antiretroviral therapy, and exploring the minimum host requirements of high level HIV control.

UCL leads the overall project and will take a substantial role in WP1: Management, particularly in coordination of the consortium; WP2: Biomedical Research Activities, particularly in leading the molecularly-based medicine exemplar research; and WP6: Workflows and Performance, including the deployment of an informatics platform to store data from the project as well as other software tools such as HemeLB, BAC and AHE.