The Research Programme on Biomedical Informatics (GRIB, http://grib.upf.edu) is a joint research programme of IMIM-Hospital del Mar Research Institute and Universitat Pompeu Fabra (UPF) located at the Barcelona Biomedical Research Park (PRBB). It is funded by AGAUR.
GRIB’s mission is to develop and apply computational methods and information technologies for a better understanding and prediction of biological phenomena, giving especial emphasis to pharmacological treatment. GRIB has extensive experience in the participation and coordination of transnational research projects. The list of the on-going European projects of the programme includes eTOX, OpenPHACTS, EMIF and RNPnet.
GRIB is currently composed of more than 70 members, organized in 9 research groups. The research activity of GRIB has led to the creation of several spin-off companies including Pharmatools, Chemotargets and Acellera Ltd.
GRIB is the coordinator of the Plataforma Tecnológica Española de Medicamentos Innovadores (PTEMI), jointly with Farmaindustria, is the node for Biomedical Informatics of the Spanish Institute of Bioinformatics (INB) and is deeply involved in the Bioinformatics Barcelona (BIB) platform which aims to boost training, research, and the transfer of technology in bioinformatics.
The research interests of the laboratory are at the interface between computation and biology, with an application focus on biomedicine. Specifically, the group develops new computational physics methods and applies them to understand biological problems mainly at the level of protein folding and binding. This knowledge is then used to design molecules with therapeutic applications in mind. The group has three main research lines:
- Biomedicine: search of new molecules to alter protein behaviour with possible therapeutic implications, using new simulation-based methods for drug discovery.
- Computational physics: development of new codes for molecular dynamics simulations running on special hardware to maximize the data throughput and extend the window of exploration of biological phenomena by simulations.
- Protein folding and binding: computationally investigate biological systems to understand the mechanisms of biological processes at the atomistic level.
UPF will play a substantial role in WP2 (Task 2.3) Molecularly-based Medicine Exemplar Research and in WP6: Empowering Biomedical Applications.