PolNet is a software tool for the computer simulation of blood flow in realistic microvascular networks imaged with a wide variety of microscopy and clinical imaging techniques. To date, PolNet has contributed to: a) uncovering the relationship between blood flow and blood vessel biology and its importance for correct vascularisation of tissues, and b) developing ways of predicting retinal vascular damage in diabetic retinopathy patients. PolNet facilitates the adoption of cutting-edge computer simulation technology by non-experts in the Biosciences.
Clinical research, Clinical decision support, Developmental biology research.
Simulation of large scale vascular networks.
- Bernabeu MO, Jones ML, Nash RW, Pezzarossa A, Coveney PV, Gerhardt H, Franco CA., PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling. Biophys J. 2018 May 8;114(9):2052-2058.