PolNet is a open-source software tool for the computer simulation of blood flow and cell-level biological activity during vessel morphogenesis imaged with a wide variety of microscopy and clinical imaging techniques. To date, PolNet has contributed to: a) uncovering the relationship between blood flow and blood vessel biology and its importance for correct vascularisation of tissues, and b) developing ways of predicting retinal vascular damage in diabetic retinopathy patients. PolNet facilitates the adoption of cutting-edge computer simulation technology by non-experts in the Biosciences.
Barbacena P, Dominguez-Cejudo M, Fonseca CG, Gómez-González M, Faure LM, Zarkada G, Pena AA, Pezzarossa A, Ramalho D, Giarratano Y, Ouarné M, Barata D, Fortunato I, Misiková LH, Mauldin I, Carvalho Y, Trepat X, Roca-Cusachs P, Eichmann A, Bernabeu MO, Franco CA. Competition for endothelial cell polarity drives vascular morphogenesis. Under review at Developmental Cell, preprint: https://doi.org/10.1101/2021.11.23.469704, 2022.
Jin Y, Ding Y, Richards M, Kaakinen M, Szymborska A, Rosa A, Baumann E, Giese W, Pena A, Nwadozi E, Jamalpour M, Sainz M, Vestweber D, Welsh M, Bernabeu MO, Franco CA, Eklund L, Gerhardt H, Claesson-Welsh L. YES kinase controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Undergo- ing revision for Nature Cardiovascular Research, preprint: https://doi.org/10.21203/rs.3.rs- 1196695/v1, 2022.
Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO. Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks. Journal of the Royal Society Interface 18:20210113, 2021.
Bernabeu MO, Köry J, Grogan JA, Markelc B, Beardo A, d’Avezac M, Kaeppler J, Daly N, Hetherington J, Krüger T, Maini PK, Pitt-Francis JM, Muschel RJ, Alarcón T, Byrne HM. Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. PNAS 117(45) 27811-27819, 2020.