The Royal Society’s Interface Focus, CompBioMed Conference 2019 Themed Issue – Part II

We are delighted to announce that Computational Biomedicine. Part II: Organs and Systems of a two-part Theme Issue resulting from papers originally submitted to the CompBioMed Conference 2019 has now been published in The Royal Society’s “Interface Focus” journal, with articles available for all to read as open source.

Part II concentrates on organs and systems and follows from Part I: Molecular Medicine, which was published on 16 October 2020

Picture featured on the front cover of the journal and taken from the Virtual Humans Film produced by CompBioMed

In this issue you will find an Introduction by our Coordinator, Prof. Peter Coveney, describing the work that has been done and still needs to be done in the field of Computational Biomedicine and, in particular, in the area of organs and systems, which the Issue deals with.

The other articles are:

Haemodynamic flow conditions at the initiation of high-shear platelet aggregation: a combined in vitro and cellular in silico study
B. J. M. van Rooij, G. Závodszky, A. G. Hoekstra and D. N. Ku

Digital blood in massively parallel CPU/GPU systems for the study of platelet transport
C. Kotsalos, J. Latt, J. Beny and B. Chopard

Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke
R. M. Padmos, T. I. Józsa, W. K. El-Bouri, P. R. Konduri, S. J. Payne and A. G. Hoekstra

A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke
T. I. Józsa, R. M. Padmos, N. Samuels, W. K. El-Bouri, A. G. Hoekstra and S. J. Payne

Applicability assessment of a stent-retriever thrombectomy finite-element model
G. Luraghi, J. Felix Rodriguez Matas, G. Dubini, Francesca Berti, S. Bridio, S. Duffy, A. Dwivedi, R. McCarthy, B. Fereidoonnezhad, P. McGarry, C. B. L. M. Majoie, F. Migliavacca and on behalf of the INSIST investigators

Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability
H. Martinez-Navarro, X. Zhou, A. Bueno-Orovio and B. Rodriguez

The EurValve model execution environment
M. Bubak, K. Czechowicz, T. Gubała, D. R. Hose, M. Kasztelnik, M. Malawski, J. Meizner, P. Nowakowski and S. Wood

Towards blood flow in the virtual human: efficient self-coupling of HemeLB
J. W. S. McCullough, R. A. Richardson, A. Patronis, R. Halver, R. Marshall, M. Ruefenacht, B. J. N. Wylie, T. Odaker, M. Wiedemann, B. Lloyd, E. Neufeld, G. Sutmann, A. Skjellum, D. Kranzlmüller and P. V. Coveney

Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise
G. Ascolani, T. M. Skerry, D. Lacroix, E. Dall’Ara and A. Shuaib

Deep medical image analysis with representation learning and neuromorphic computing
N. Getty, T. Brettin, D. Jin, R. Stevens and F. Xia